Roles of G‐protein‐coupled receptor dimerization
نویسندگان
چکیده
منابع مشابه
G-protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
متن کاملStepwise androgen receptor dimerization.
Androgen-regulated gene expression is a highly coordinated dynamic process mediated by androgen receptor (AR) ligand binding and DNA binding, and by specific AR protein-protein interactions. The latter include DNA-binding domain (D-box) interactions in AR homodimers, and the interaction of the FQNLF motif in the AR N-terminal domain and the coactivator groove in the ligand-binding domain (N/C i...
متن کاملAdrenergic Receptor Dimerization
G protein-coupled receptors (GPCRs) constitute the largest and most diverse family of the mammalian membrane receptors (Pierce et al. 2002 ). Members of the GPCR superfamily are involved in mediating several physiological processes and respond to a wide range of ligands (Rosenbaum et al. 2009 ). As a result, more than half of the current clinical drugs target GPCRs (Heilker et al. 2009 ). Membe...
متن کاملRoles of G-protein-coupled receptor dimerization From ontogeny to signalling regulation
The classical idea that G-protein-coupled receptors (GPCRs) function as monomeric entities has been unsettled by the emerging concept of GPCR dimerization. Recent findings have indicated not only that many GPCRs exist as homodimers and heterodimers, but also that their oligomeric assembly could have important functional roles. Several studies have shown that dimerization occurs early after bios...
متن کاملReceptor signaling: Dimerization and beyond
It is has been proposed that hormone receptors which have only a single transmembrane sequence mediate signaling via hormone-induced monomer-to-dimer transitions. But recent studies of analogous receptors in bacteria indicate that dimerization may be only a prerequisite for signaling.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EMBO reports
سال: 2004
ISSN: 1469-221X,1469-3178
DOI: 10.1038/sj.embor.7400052